EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.2.2.1 | 2'-deoxyadenosine | - |
Leishmania mexicana | |
3.2.2.1 | 2'-deoxyinosine | - |
Leishmania mexicana | |
3.2.2.1 | adenosine | potent | Leishmania mexicana | |
3.2.2.1 | hypoxanthine arabinoside | - |
Leishmania mexicana | |
3.2.2.1 | purine 2'-deoxyribonucleoside | - |
Leishmania mexicana | |
3.2.2.1 | pyrazolo(3,4-d)pyrimidine | - |
Leishmania mexicana | |
3.2.2.1 | Xanthosine | moderate | Leishmania mexicana | |
3.2.2.8 | 4,6-Dihydroxy-1-beta-D-ribofuranosylpyrazolo-(3,4-d) pyrimidine | - |
Leishmania donovani | |
3.2.2.8 | 4-Hydroxyl-1-beta-D-ribofuranosylpyrazolo-(3,4-d) pyrimidine | - |
Leishmania donovani | |
3.2.2.8 | 4-Methylthio-1-beta-D-ribofuranosylpyrazolo-(3,4-d)pyrimidine | - |
Leishmania donovani | |
3.2.2.8 | 4-Thio-1-beta-D-ribofuranosylpyrazolo-(3,4-d)pyrimidine | - |
Leishmania donovani | |
3.2.2.8 | adenosine | - |
Leishmania donovani | |
3.2.2.8 | guanosine | - |
Leishmania donovani | |
3.2.2.8 | additional information | poor inhibitors | Leishmania donovani |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.2.2.8 | 0.33 | - |
6-mercaptopurine ribonucleoside | - |
Leishmania donovani | |
3.2.2.8 | 0.62 | - |
Inosine | - |
Leishmania donovani | |
3.2.2.8 | 0.78 | - |
purine ribonucleoside | - |
Leishmania donovani | |
3.2.2.8 | 1.06 | - |
uridine | - |
Leishmania donovani | |
3.2.2.8 | 1.11 | - |
Xanthosine | - |
Leishmania donovani | |
3.2.2.8 | 5.5 | - |
uridine | - |
Leishmania donovani |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.2.2.1 | 205000 | - |
gel filtration | Leishmania mexicana |
3.2.2.8 | 180000 | - |
gel filtration | Leishmania donovani |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.2.2.8 | N-D-ribosylpyrimidine | Leishmania donovani | - |
pyrimidine + D-ribose | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.2.2.1 | Leishmania mexicana | - |
- |
- |
3.2.2.8 | Leishmania donovani | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.2.2.8 | - |
Leishmania donovani |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.2.2.8 | promastigote | - |
Leishmania donovani | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
3.2.2.8 | 8.5 | - |
substrate: uridine | Leishmania donovani |
EC Number | Storage Stability | Organism |
---|---|---|
3.2.2.1 | -20°C, 5% loss of activity after 30 days | Leishmania mexicana |
3.2.2.8 | 3°C, cell extract heated for 10 min at 55°C before passage through a DEAE-cellulose column, enzyme thus purified loses 5% of activity after 30 days | Leishmania donovani |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.2.2.1 | 6-mercaptopurine ribonucleoside + H2O | - |
Leishmania mexicana | 6-mercaptopurine + ribose | - |
? | |
3.2.2.1 | adenosine + H2O | no activity | Leishmania mexicana | D-ribose + adenine | - |
? | |
3.2.2.1 | guanosine + H2O | - |
Leishmania mexicana | D-ribose + guanine | - |
? | |
3.2.2.1 | inosine + H2O | - |
Leishmania mexicana | hypoxanthine + D-ribose | - |
? | |
3.2.2.1 | purine ribonucleoside + H2O | - |
Leishmania mexicana | purine + D-ribose | - |
? | |
3.2.2.1 | xanthosine + H2O | no activity | Leishmania mexicana | D-ribose + xanthine | - |
? | |
3.2.2.8 | 6-mercaptopurine ribonucleoside + H2O | - |
Leishmania donovani | 6-mercaptopurine + D-ribose | - |
? | |
3.2.2.8 | cytidine + H2O | - |
Leishmania donovani | cytosine + D-ribose | - |
? | |
3.2.2.8 | inosine + H2O | - |
Leishmania donovani | hypoxanthine + D-ribose | - |
? | |
3.2.2.8 | additional information | not: adenosine and guanosine | Leishmania donovani | ? | - |
? | |
3.2.2.8 | N-D-ribosylpyrimidine | - |
Leishmania donovani | pyrimidine + D-ribose | - |
? | |
3.2.2.8 | N-D-ribosylpyrimidine + H2O | - |
Leishmania donovani | pyrimidine + D-ribose | - |
? | |
3.2.2.8 | purine D-ribonucleosides + H2O | appreciable substrate activity if a hydroxyl or thio group is present in the 6-position or if a hydroxyl group is present in the 2- and 6-position, preference for oxo versus amino substituents | Leishmania donovani | purine + D-ribose | - |
? | |
3.2.2.8 | purine D-ribonucleosides + H2O | prefers pyrimidines | Leishmania donovani | purine + D-ribose | - |
? | |
3.2.2.8 | uridine + H2O | cleaves uridine most efficiantly | Leishmania donovani | uracil + D-ribose | - |
? | |
3.2.2.8 | xanthosine + H2O | - |
Leishmania donovani | xanthine + D-ribose | - |
? |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.2.2.8 | 55 | - |
after 2 min: all of the uridine-cleaving activity and 62% of the inosine-cleaving activity remains | Leishmania donovani |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.2.2.1 | 6.7 | - |
- |
Leishmania mexicana |
3.2.2.8 | 6.5 | - |
substrate: uridine | Leishmania donovani |